艾熙和苏语棠饰演母女Thefifth-yearresidentsreturnforthefirstdayofayearthatwillmakeorbreaktheircareers:MeredithfacestheconsequencesoftamperingwithDerek’sclinicaltrialandisterminatedatthehospital;ApriltriestostepuptotheplateasChiefResidentinthewakeofagiantsinkholeinthemiddleofSeattle;andCristinaandOwenarestillatoddsovertheirdrasticallydifferentfeelingsfortheirunbornchild.